Chiang, Yi-ChangYi-ChangChiangLeu, Wohn-JennWohn-JennLeuChen, Yi-ChinYi-ChinChenYe, Pei-ChenPei-ChenYeHsu, Yu-TungYu-TungHsuHsiao, Yu-ChiYu-ChiHsiaoHsu, Jui-LingJui-LingHsuChan, She-HungShe-HungChanLIH-CHING HSUHuang, Hsu-ShanHsu-ShanHuangJIH-HWA GUH2024-03-192024-03-192023-1202704137https://scholars.lib.ntu.edu.tw/handle/123456789/641120Castration-resistant prostate cancer (CRPC) is refractory to hormone treatment and the therapeutic options are continuously advancing. This study aims to discover the anti-CRPC effects and underlying mechanisms of small-molecule compounds targeting topoisomerase (TOP) II and cellular components of DNA damage repair.enG2 arrest; Rad51 inhibition; castration-resistant prostate cancer; dual function inhibitors; topoisomerase II inhibitors[SDGs]SDG3Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancerjournal article10.1002/pros.24613375831032-s2.0-85168089531https://api.elsevier.com/content/abstract/scopus_id/85168089531