ARISTINE CHENGHolland, Steven MSteven MHolland2022-05-252022-05-2520220091-6749https://scholars.lib.ntu.edu.tw/handle/123456789/612063Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.enAnticytokine autoantibodies; adult-onset immunodeficiency; anti-IFN-alpha; anti–CM-CSF; anti–IFN-γ; anti–IL-12; anti–IL-17; anti–IL-23; chronic mucocutaneous candidiasis; opportunistic infections; protein alveolar proteinosisreview10.1016/j.jaci.2021.11.016349984742-s2.0-85121623619WOS:000744544500003https://api.elsevier.com/content/abstract/scopus_id/85121623619