Lee Y.-C.ALi SChen YLi QChen C.-JHsu W.-LPEI-JEN LOUZhu CPan JShen HMa HCai LHe BWang YZhou XJi QZhou BWu WMa JBoffetta PZhang Z.-FDai MHashibe M.2020-10-272020-10-2720191043-3074https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058368730&doi=10.1002%2fhed.25383&partnerID=40&md5=0b9bccbaeab9158a1d89b66a420b82efhttps://scholars.lib.ntu.edu.tw/handle/123456789/518183Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia. Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. The odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression. Results: Head and neck cancer risks were elevated for tobacco (OR = 1.58), betel quid (OR = 8.23), and alcohol (OR = 2.29). The total attributable risk of tobacco and/or alcohol was 47.2%. Tobacco/alcohol appeared to account for a small proportion of head and neck cancer among women (attributable risk of 2.2%). Betel quid chewing alone accounted for 28.7% of head and neck cancer. Conclusions: Betel quid chewing is the strongest risk factor for oral cavity cancer in this Chinese population. Alcohol may play a larger role for head and neck cancer in this population than in European or U.S. populations. ? 2018 Wiley Periodicals, Inc.alcohol drinking; attributable fraction, head and neck cancer risk; betel quid chewing; tobacco smoking[SDGs]SDG3alcohol; adult; aged; Article; betel quid; cancer risk; case control study; cigarette smoking; controlled study; drinking behavior; East Asian; female; head and neck cancer; human; hypopharynx cancer; larynx cancer; major clinical study; mastication; middle aged; mouth cancer; multicenter study; oropharynx cancer; priority journal; smoking; adverse event; Areca; Asian continental ancestry group; clinical trial; drinking behavior; Far East; head and neck tumor; male; risk factor; smoking; Aged; Alcohol Drinking; Areca; Asian Continental Ancestry Group; Case-Control Studies; Far East; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Risk Factors; Tobacco Smokingjournal article10.1002/hed.25383305528262-s2.0-85058368730