Hsieh C.-H.Kuo Y.-S.Liao L.-J.Hu K.-Y.Lin S.-C.Wu L.-J.Lin Y.-C.Chen Y.LI-YING WANGHsieh Y.-P.Lin S.L.Chen C.-Y.Chen C.-A.Shueng P.-W.2020-06-292020-06-2920111471-2407https://www.scopus.com/inward/record.uri?eid=2-s2.0-79251567669&doi=10.1186%2f1471-2407-11-37&partnerID=40&md5=bebca07cce8b77a18ca8a8ffe1e0ece6https://scholars.lib.ntu.edu.tw/handle/123456789/506313Background: The aim of this study was to assess the treatment results and toxicity profiles of helical tomotherapy (HT) for postoperative high-risk oral cavity cancer.Methods: From December 6, 2006 through October 9, 2009, 19 postoperative high-risk oral cavity cancer patients were enrolled. All of the patients received HT with (84%) or without (16%) chemotherapy.Results: The median follow-up time was 17 months. The 2-year overall survival, disease-free survival, locoregional control, and distant metastasis-free rates were 94%, 84%, 92%, and 94%, respectively. The package of overall treatment time > 13 wk, the interval between surgery and radiation ? 6 wk, and the overall treatment time of radiation ? 7 wk was 21%, 84%, and 79%, respectively. The percentage of grade 3 mucositis, dermatitis, and leucopenia was 42%, 5% and 5%, respectively.Conclusions: HT achieved encouraging clinical outcomes for postoperative high-risk oral cavity cancer patients with high compliance. A long-term follow-up study is needed to confirm these preliminary findings. ? 2011 Hsieh et al; licensee BioMed Central Ltd.[SDGs]SDG3cisplatin; fluorouracil; folinic acid; antineoplastic agent; adult; aged; anemia; article; cancer control; cancer survival; chemoradiotherapy; clinical article; controlled study; dermatitis; disease free survival; distant metastasis; female; human; intensity modulated radiation therapy; leukopenia; male; mouth cancer; mucosa inflammation; oral surgery; overall survival; patient compliance; postoperative care; retrospective study; thrombocytopenia; tomotherapy; treatment outcome; weight reduction; xerostomia; clinical trial; drug effect; intensity modulated radiation therapy; leukopenia; methodology; middle aged; mouth; mouth tumor; mucosa inflammation; multimodality cancer therapy; postoperative care; radiation dermatitis; radiation dose; radiation exposure; risk factor; spiral computer assisted tomography; Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Leukopenia; Male; Middle Aged; Mouth; Mouth Neoplasms; Mucositis; Postoperative Care; Radiodermatitis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Risk Factors; Tomography, Spiral Computed; Treatment Outcome; Young Adultjournal article10.1186/1471-2407-11-37212695182-s2.0-79251567669