SUNG-CHUN TANGSHIN-JOE YEHLI-KAI TSAIHu C.-J.Lien L.-M.Peng G.-S.WEI-SHIUNG YANGChiou H.-Y.JIANN-SHING JENG2020-03-022020-03-0220160028-3878https://scholars.lib.ntu.edu.tw/handle/123456789/467918Objective: To investigate the expression patterns of 2 soluble isoforms of receptor for advanced glycation end-product (RAGE), including endogenous secretory RAGE (esRAGE) and cleaved RAGE (cRAGE), and their associations with outcome in acute ischemic stroke (IS). Methods: Acute IS patients (n = 106) and age- and sex-matched controls (n = 150) were recruited. Plasma levels of total soluble RAGE (sRAGE) and esRAGE in patients at <48 hours and 48-72 hours after IS and in controls were measured by ELISA. The level of cRAGE was calculated by subtracting the level of sRAGE from that of esRAGE. Poor outcome was defined as modified Rankin Scale score <2 at 3 months after stroke. Results: The plasma levels of cRAGE were significantly higher and correlated to those of esRAGE (p<0.001). The plasma levels of esRAGE and cRAGE were both significantly higher in IS patients < 48 hours and 48-72 hours after onset than in controls, but only level of cRAGE at <48 hours was independently associated with poor outcome after adjusting for clinical variables (odds ratio 2.44; 95% confidence interval 1.16-5.16; p = 0.019). Conclusion: The plasma level of cRAGE at <48 hours after IS, rather than esRAGE, is a significant predictor of acute IS outcome. ? 2015 American Academy of Neurology.[SDGs]SDG3advanced glycation end product receptor; cleaved advanced glycation end product receptor; endogenous secretory advanced glycation end product receptor; glucose; soluble isoforms of receptor for advanced glycation end product; unclassified drug; advanced glycation end product receptor; biological marker; esRAGE protein, human; sRAGE protein, human; adult; age; Article; atrial fibrillation; brain ischemia; controlled study; diabetes mellitus; enzyme linked immunosorbent assay; female; human; hyperlipidemia; hypertension; major clinical study; male; National Institutes of Health Stroke Scale; outcome assessment; priority journal; protein blood level; Rankin scale; aged; blood; brain ischemia; follow up; middle aged; procedures; Stroke; time factor; Advanced Glycosylation End Product-Specific Receptor; Aged; Biomarkers; Brain Ischemia; Female; Follow-Up Studies; Humans; Male; Middle Aged; Outcome Assessment (Health Care); Stroke; Time Factorsjournal article10.1212/WNL.0000000000002287266836432-s2.0-84955268218