Shabudin, AbbasAbbasShabudinNik Mohamed, Nik AbdullahNik AbdullahNik MohamedEl-Bouri, WahbiWahbiEl-BouriSTEPHEN JOHN PAYNEMohamed Mokhtarudin, Mohd JamilMohd JamilMohamed Mokhtarudin2025-11-252025-11-252025-1009391533https://www.scopus.com/record/display.uri?eid=2-s2.0-105018668297&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/734144The cerebral microvasculature plays a key role in determining the blood perfusion and oxygen diffusion to surrounding tissue. Multiscale models have thus been developed to incorporate the effect of the microvasculature into overall brain function. Moreover, brain tissue poroelastic properties are also influenced by the microvasculature. This study aims to determine the pororelastic properties of brain tissue using multiscale modeling on microvasculature networks described by the following effective parametric tensors: blood flow permeability K, interstitial fluid flow permeability G, Biot’s coefficients for blood αc and interstitial fluid αt, Young’s modulus E¯, and Poisson’s ratio v¯. The microvasculature networks are built from a morphometric data of brain capillary distribution, which is represented using 1D lines. To allow for solving the microscale cell equations using finite element method, the microvasculature is modified into 3D shapes. The modifications resulted in 15% increment of the microvasculature volume. Validation is then performed by comparing the permeability tensor K obtained using Poiseuille’s and Stokes’ equations, which resulted in the value of K obtained through solving Stokes’ equation to be about 70% less than through solving Poiseuille’s equation. Based on these results, the other effective parameters have been estimated by considering the microvasculature volume increment due to the geometry modification. The volume increment significantly affects the parameter αc but not the other parameters. The effective parameters are then used in a benchmark simulation, which further demonstrates the model value in describing the effects of brain capillary morphology in cerebrovascular diseases.trueCapillary networkMultiscale modelParameter estimationPoroelastic properties[SDGs]SDG3journal article10.1007/s00419-025-02954-w2-s2.0-105018668297