CHIH-YUAN WANGYu T.-Y.SHYANG-RONG SHIHKUO-CHIN HUANGTIEN-CHUN CHANG2019-10-242019-10-242018-06-16https://scholars.lib.ntu.edu.tw/handle/123456789/427398This study examined associations of thyroid hormone levels and insulin resistance (IR) in non-diabetic individuals. Using a cross-sectional design, 2007–2008 data from the National Health and Nutrition Examination Survey (NHANES) were analyzed. NHANES participants ≥20 years of age with complete data of interest were included. The homeostatic model assessment (HOMA) was used to quantify IR, and treated as a continuous variable. Self-reported diabetes or a fasting glucose ≥7mmol/L were used as criteria to exclude diabetic subjects. Race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, hemoglobin A1C (HbA1C), high-density lipoprotein, triglyceride, vitamin D and C-reactive protein were covariates signifcantly associated with HOMA-IR. A total of 1,560 non-diabetic subjects were included in the analysis. When adjusted for all factors signifcant in the univariate analysis (race, liver function, obesity, hypertension, dyslipidemia, smoking, physical activity, vigorous recreational activity, 2-hour glucose, HbA1C, high-density lipoprotein, triglyceride, vitamin D, and CRP) low total triiodothyronine (TT3) and low free T3 (FT3) were signifcantly associated with decreased HOMA-IR (adjusted coefcient=−0.486, 95% confdence interval [CI]: −0.936, −0.036; adjusted coefcient=−1.151, 95% CI: −1.952, −0.350, respectively). Insulin resistance is associated with low thyroid hormone levels in non-diabetic individuals.en-USDiabetes, HOMA-IR, Insulin resistance, NHANES, Thyroid hormones[SDGs]SDG3glycosylated hemoglobin; liothyronine; adult; blood; cross-sectional study; female; glucose blood level; human; insulin resistance; male; middle aged; nutrition; United States; young adult; Adult; Blood Glucose; Cross-Sectional Studies; Female; Glycated Hemoglobin A; Humans; Insulin Resistance; Male; Middle Aged; Nutrition Surveys; Triiodothyronine; United States; Young Adultjournal article10.1038/s41598-018-29087-1