Wang I.-J.LI-MIN HUANGYue Leon GuoHsieh W.-S.Lin T.-J.PAU-CHUNG CHEN2021-06-242021-06-2420120929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-84871615965&doi=10.1016%2fj.jfma.2011.09.022&partnerID=40&md5=6992b6a6b9070ebf35b46b4f3d8821e3https://scholars.lib.ntu.edu.tw/handle/123456789/566475Background/Purpose: Epidemiologic evidence for an association between vaccinations and atopy development is inconsistent. We evaluated the influence of Haemophilus influenzae type b (Hib) combination vaccines in 6-month-old infants on the prevalence of atopic disorders in 18-month-old children. Methods: We used multistage, stratified systematic sampling to recruit 24,200 mother-newborn pairs from the Taiwan national birth registration in 2005. Vaccination status was ascertained through official vaccine cards, while risk factors for atopic disorders were gathered by questionnaires at 6 months of age. Information about development of atopic dermatitis (AD) and recurrent wheezing was collected at 18 months of age. The relationship between atopic disorders and Hib combination vaccines, diphtheria-pertussis-tetanus-Hib and oral poliomyelitis vaccines (DPT-Hib&OPV) and DPT-Hib-inactivated poliomyelitis vaccines (DPT-Hib-IPV), were estimated by multiple logistic regression. Results: A total of 19,968 children completed the follow-up and participated in the study. AD was noted in 1584 (7.9%) infants while recurrent wheezing was found in 1220 (6.1%) infants. The adjusted odds ratios (ORs) (95% CI) for the development of AD in the DPT-Hib&OPV and DPT-Hib-IPV vaccination groups were given as 1.38 (1.15-1.65) and 1.49 (1.29-1.72), compared to those without Hib vaccination (DTP&OPV vaccination). However, the association between DPT-Hib&OPV and DPT-Hib-IPV vaccinations and recurrent wheezing failed to reach statistical significance. Conclusion: There is a potential risk for AD after receiving Hib combination vaccines. Hib vaccination is important to the public health, and therefore the observation requires further investigations. ? 2012 .Atopic dermatitis; Haemophilus influenzae type b; Recurrent wheezing; Vaccines[SDGs]SDG3diphtheria pertussis poliomyelitis tetanus Haemophilus influenzae type b hepatitis B vaccine; Haemophilus influenzae type b vaccine plus hepatitis B vaccine; adverse outcome; article; atopic dermatitis; controlled clinical trial; controlled study; drug safety; female; human; infant; influenza B; influenza vaccination; major clinical study; male; questionnaire; risk factor; vaccination; wheezing; Dermatitis, Atopic; Diphtheria-Tetanus-Pertussis Vaccine; Female; Haemophilus Vaccines; Humans; Infant; Male; Poliovirus Vaccine, Inactivated; Poliovirus Vaccine, Oral; Prevalence; Prospective Studies; Risk Factors; Taiwanjournal article10.1016/j.jfma.2011.09.022232657512-s2.0-84871615965