Pek, SSPekTONG-YUAN TAICrowther, RRCrowtherFajans, S SS SFajans2023-05-312023-05-311976-090012-1797https://scholars.lib.ntu.edu.tw/handle/123456789/631656The dynamics and interrelationships of glucagon and insulin secretion were studied in the isolated perfused rat pancreas by utilizing a series of compounds that stimulate the release of both hormone. Leucine, arginine, prostaglandins F2alpha and E2, bovine growth hormone, and isoproterenol were administered individually over 60-second intervals. The release of glucagon preceded that of insulin in response to all compounds tested. The rapidity of glucagon release varied in response to different secretagogues; the time course of insulin release was fairly constant. The timing and the magnitude of glucagon and insulin release did not correlate statistically.enjournal article10.2337/diab.25.9.7647829852-s2.0-0017106212https://api.elsevier.com/content/abstract/scopus_id/0017106212