KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation

Serrano C.Wang Y.Mariño-Enríquez A.JEN-CHIEH LEERavegnini G.Morgan J.A.Bertagnolli M.M.Beadling C.Demetri G.D.Corless C.L.Heinrich M.C.Fletcher J.A.2020-03-072020-03-0720150732-183Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84941283441&doi=10.1200%2fJCO.2013.48.7488&partnerID=40&md5=cc8667f5b2a289e372dac78d8f909704https://scholars.lib.ntu.edu.tw/handle/123456789/473701[SDGs]SDG2[SDGs]SDG3CD34 antigen; imatinib; phosphatidylinositol 3 kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; protein kinase B; antineoplastic agent; arginine; benzamide derivative; glycine; imatinib; isoleucine; KRAS protein, human; MTOR protein, human; oncoprotein; phosphatidylinositol 3 kinase; piperazine derivative; protein kinase B; protein kinase inhibitor; pyrimidine derivative; Ras protein; stem cell factor receptor; target of rapamycin kinase; threonine; abdominal radiography; adult; Article; cancer growth; cancer resistance; case report; computer assisted tomography; drug megadose; endoscopic biopsy; enzyme activity; exon; fatigue; follow up; gastrointestinal stromal tumor; gene mutation; hematocrit; human; human tissue; immunoblotting; liver metastasis; male; middle aged; missense mutation; nausea; oncogene c kit; oncogene K ras; postoperative period; priority journal; protein expression; shoulder pain; thrombocyte count; treatment duration; carcinoma; DNA sequence; drug resistance; Gastrointestinal Stromal Tumors; genetics; metabolism; mutation; signal transduction; Stomach Neoplasms; time; Antineoplastic Agents; Arginine; Benzamides; Carcinoma; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Glycine; Humans; Imatinib Mesylate; Isoleucine; Male; Middle Aged; Mutation; Phosphatidylinositol 3-Kinase; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Pyrimidines; ras Proteins; Sequence Analysis, DNA; Signal Transduction; Stomach Neoplasms; Threonine; Time Factors; TOR Serine-Threonine KinasesKRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulationjournal article10.1200/JCO.2013.48.7488246878222-s2.0-84941283441