KUAN-YU HUNGJENQ-WEN HUANGTUN-JUN TSAIChen Wan Yu2020-12-242020-12-2420000160-564Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0034017971&doi=10.1046%2fj.1525-1594.2000.06478.x&partnerID=40&md5=2170ad49d761485315c4f7b5246283f3https://scholars.lib.ntu.edu.tw/handle/123456789/531875We conducted a retrospective, 7 year cohort survey to examine the natural changes in peritoneal equilibration test (PET) results in patients with long-term uneventful continuous ambulatory peritoneal dialysis (CAPD). Thirty-two (17 males, 15 females) patients on CAPD with two or more standard PETs performed more than 6 months apart, in the absence of peritoneal insult, were included. Changes and pattern of PET results were evaluated by the dialysate to plasma ratio of creatinine (D:P-cre), the fourth h dialysate to instilled glucose ratio (D4:Do) and ultrafiltration volume (UF, ml). The subgroups included high (H), high-average (HA), low-average (LA), or low (L) transporters with the dividing ratios (D:P-cre) of >0.81, >0.65 to 0.81, >0.5 to 0.65, and <0.5, respectively. The median D:P-cre significantly decreased (p = 0.04), but neither the D4:Do nor the final median UF significantly decreased. The change in D:P-cre was strongly and inversely correlated with the initial D:P-cre value (r = -0.68; p < 0.05). A similar relationship was found between the change in the final D4:Do and the initial D4:Do (r = - 0.752; p < 0.01) and between the change in the final UF and the initial UF (r = -0.875; p < 0.01). No correlation was found between the change in D:P-cre and the age of the patient, the time interval between PETs, monthly dialysate glucose exposure, or underlying diabetes/non-diabetes. The final peritoneal transport pattern was altered with 5 (15.6%) patients remaining in the extreme subgroups (H or L) and, by contrast, 84.4% (27/32) of the patients now in the averaged (HA or LA) groups (p < 0.01, χ2 test). We demonstrated a natural 'centralization' migration of PET results after long-term uneventful CAPD, which may help to explain why patients with extreme PET characteristics, that is, H or L, continued to do well on CAPD.[SDGs]SDG3Dialysis; Surveys; Testing; Centralisation; Continuous ambulatory peritoneal dialysis; Dialysates; Lower average; Peritoneal dialysis; Peritoneal equilibration test; Peritoneal transport; Time interval; Transport patterns; χ+2$/ test; Glucose; article; clinical article; continuous ambulatory peritoneal dialysis; female; human; kidney disease; long term care; male; patient monitoring; peritoneal catheter; peritoneal equilibration test; peritonitis; priority journaljournal article10.1046/j.1525-1594.2000.06478.x108161982-s2.0-0034017971