Chou MCKo CWChiu YHLai PHHSIAO-WEN CHUNG2019-10-312019-10-31201715323145https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038129382&doi=10.1097%2fRCT.0000000000000621&partnerID=40&md5=3c7ed50f6d9cf05eb166a24a5b216930PURPOSE: Diffusion kurtosis imaging (DKI) has been widely used to characterize brain tissue alterations. Diffusion-weighting factor or b value plays an important role in the measurement of rapid DKI and may have influential effects on them. The purpose of this study was to investigate the effects of b value on rapid DKI indices in normal and acute ischemic brain tissues.MATERIALS AND METHODS: This study enrolled 10 healthy subjects and 4 acute ischemic stroke patients. Three repeated DKI data with 6 high b values (500, 750, 1000, 1500, 2000, 3000 s/mm) were acquired from healthy subjects, whereas nonrepeated DKI data with 3 high b values (1000, 2000, 3000 s/mm) were acquired from ischemic stroke patients. The DKI datasets were decomposed into several rapid DKI datasets consisting of 1 b0 and 2 high b values for comparisons.RESULTS: The results showed that b value significantly impacted the reproducibility and accuracy of DKI indices. The comparisons demonstrated that DKI with b = (0, 1000, 3000) s/mm exhibited more reproducible and accurate DKI indices than other DKI datasets in normal brain tissues, and similar results were noticed in acute ischemic brain tissue.CONCLUSIONS: We concluded that b value significantly impacted the quantification of DKI indices in both normal and acute ischemic brain tissues.Accuracy; B value; Diffusion kurtosis imaging; Ischemic stroke; Reproducibility[SDGs]SDG3brain ischemia; cerebrovascular accident; diagnostic imaging; diffusion tensor imaging; diffusion weighted imaging; female; human; male; middle aged; procedures; reproducibility; time factor; young adult; Brain Ischemia; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Female; Humans; Male; Middle Aged; Reproducibility of Results; Stroke; Time Factors; Young AdultEffects of b value on quantification of rapid diffusion kurtosis imaging in normal and acute ischemic brain tissuesjournal article10.1097/rct.00000000000006212-s2.0-85038129382