Rapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysis

Lim, Ken-HongKen-HongLimLin, Huan-ChauHuan-ChauLinChen, Caleb Gon-ShenCaleb Gon-ShenChenWang, Wei-TingWei-TingWangChang, Yu-ChengYu-ChengChangChiang, Yi-HaoYi-HaoChiangLin, Ching-SungChing-SungLinSu, Nai-WenNai-WenSuSu, Ying-WenYing-WenSuLin, JohnsonJohnsonLinChang, Yi-FangYi-FangChangChang, Ming-ChihMing-ChihChangHsieh, Ruey-KuenRuey-KuenHsiehYUAN-YEH KUOWEN-CHIEN CHOU2023-02-152023-02-152015-02-020009-8981https://scholars.lib.ntu.edu.tw/handle/123456789/628139Somatic CALR exon 9 mutations have recently been identified in patients with JAK2/MPL-unmutated myeloproliferative neoplasm, and have become an important clonal marker for the diagnosis of essential thrombocythemia (ET) and primary myelofibrosis. In the present study, we sought to use high-resolution melting analysis (HRMA) as a screening method for the detection of CALR mutations.enCalreticulin (CALR); Essential thrombocythemia; High-resolution melting analysis; Mutation; Myeloproliferative neoplasmRapid and sensitive detection of CALR exon 9 mutations using high-resolution melting analysisjournal article10.1016/j.cca.2014.11.011254477042-s2.0-84911873614WOS:000349573900025https://api.elsevier.com/content/abstract/scopus_id/84911873614