Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registry

JYH-MING JIMMY JUANGYEN BIN LIUJulius Chen, Ching-YuChing-YuJulius ChenYu, Qi-YouQi-YouYuAmrita ChattopadhyayLIAN-YU LINWEN-JONE CHENCHIH-CHIEH YUHUI-CHUN HUANGLI-TING HOLING-PING LAIHWANG, JUEY-JENJUEY-JENHWANGTING TSE LINMIN-TSUN LIAOJIEN-JIUN CHENSherri Yeh, Shih-FanShih-FanSherri YehChuang, Jing-YuanJing-YuanChuangYang, Dun-HuiDun-HuiYangJIUNN-LEE LINTZU-PIN LUERIC YAO-YU CHUANG2022-09-202022-09-202020-082574-8300https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089768676&doi=10.1161%2fCIRCGEN.119.002797&partnerID=40&md5=948805e410070bf4f52de72a41422f6fBrugada syndrome (BrS) is an oligogenic arrhythmic disease with increased risk of sudden cardiac arrest. Several BrS or ECG traits-related single-nucleotide polymorphisms (SNPs) were identified through previous genome-wide association studies in white patients. We aimed to validate these SNPs in BrS patients in the Taiwanese population, assessing the cumulative effect of risk alleles and the BrS-polygenic risk score in predicting cardiac events.enBrugada syndrome; genetics; genotype; mutation; riskValidation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registryjournal article10.1161/CIRCGEN.119.002797324906902-s2.0-85089768676WOS:000576935900012