Ko Y.-C.WOEI-HORNG FANGLin T.-C.HSIN-AN HOUChen, Chien-YuanChien-YuanChenHWEI-FANG TIENLIANG-IN LIN2020-06-162020-06-1620140145-2126https://scholars.lib.ntu.edu.tw/handle/123456789/502685Let-7a-3 transcribes the miRNA let-7a, of which the expression is dysregulated in cancer. We evaluated the significance of let-7a-3 gene methylation in patients with de novo acute myeloid leukemia (AML). Let-7a-3 was methylated in 81.1% (73/90), partially methylated in 12.2% (11/90), or unmethylated in 6.7% (6/90) of patients. Let-7a-3 methylation correlated with AML karyotyping and CCAAT/enhancer binding protein α (CEBPA) methylation. Kaplan-Meier survival analysis predicted that let-7a-3 hypermethylation correlated with better survival in AML with hypomethylated CEBPA or with hypomethylated CEBPA without the favorable karyotype. We conclude that let-7a-3 methylation is a positive prognosticator for AML patients with hypomethylated CEBPA. ? 2014 Elsevier Ltd.[SDGs]SDG3Acute myeloid leukemia; CCAAT/enhancer binding protein α; DNA methylation; miRNA let-7a-3; Adolescent; Adult; Aged; Aged, 80 and over; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; DNA Methylation; Humans; Karyotyping; Leukemia, Myeloid, Acute; MicroRNAs; Middle Aged; Promoter Regions, Geneticjournal article10.1016/j.leukres.2014.03.008247031612-s2.0-84899106437