CHUNG-MIN LIAOJu Y.-R.Chen W.-Y.Chen B.-C.2020-01-142020-01-1420110048-9697https://scholars.lib.ntu.edu.tw/handle/123456789/448821The purpose of this study was to use a risk-based integrated-scale toxicological model to examine the impact of waterborne and dietborne cadmium (Cd) toxicity on rainbow trout (Oncorhynchus mykiss) susceptibility appraised with recent published data. A probabilistic assessment model was performed to estimate Cd susceptibility risk. The dose-response models were constructed based on two endpoints of % Cd in metabolically active pool (MAP) and susceptibility time that causes 50% effect (ST50). We further constructed an elimination-detoxification-recovery scheme to enhance the model predictive ability. We found a 95% probability of % Cd in gill and liver MAP exceeding 47-49% and it was likely (70% probability) to have exceeded 52-55%, but it was unlikely (30% probability) to have exceeded 56-60%. In contrast to gill and liver, gut had a relative lower Cd susceptibility risk (15-17% Cd in MAP) with a longer ST50. We suggested that the proposed probabilistic risk assessment framework can incorporate the elimination-detoxification-recovery scheme to help government based biomonitoring and bioassessment programs to prevent potential aquatic ecosystems and human health consequences. ? 2010 Elsevier B.V.Cadmium; Ecotoxicology; Modeling; Rainbow trout; Risk; Susceptibility[SDGs]SDG3Aquatic ecosystem; Bioassessment; Biomonitoring; Cadmium toxicity; Dose-response models; Eco-toxicology; Human health; Modeling; Oncorhynchus mykiss; Predictive abilities; Probabilistic assessments; Probabilistic Risk Assessment; Rainbow trout; Recovery scheme; Risk-based; Susceptibility; Cadmium; Detoxification; Ecology; Health risks; Lakes; Liver; Probability; Risk perception; Toxicity; Risk assessment; cadmium; aquatic ecosystem; biomonitoring; cadmium; detoxification; ecotoxicology; estimation method; modeling; pollution exposure; risk assessment; teleost; animal tissue; aquatic environment; article; biological model; biological monitoring; concentration response; controlled study; detoxification; ecotoxicity; ecotoxicology; environmental exposure; environmental impact assessment; mathematical model; nonhuman; prediction; priority journal; process development; rainbow trout; risk assessment; Animals; Cadmium; Diet; Dose-Response Relationship, Drug; Fresh Water; Kinetics; Models, Biological; Models, Statistical; Oncorhynchus mykiss; Risk Assessment; Risk Factors; Toxicity Tests; Water Pollutants, Chemical; Water Pollution, Chemical; Oncorhynchus mykissjournal article10.1016/j.scitotenv.2010.10.0442-s2.0-78649885400https://www2.scopus.com/inward/record.uri?eid=2-s2.0-78649885400&doi=10.1016%2fj.scitotenv.2010.10.044&partnerID=40&md5=aec8b358b1dfe243fbb1deec8a5133f6