Cheng C.-Y.WANG-HUEI SHENGLo Y.-C.Chung C.-S.YEE-CHUN CHENSHAN-CHWEN CHANG2020-12-302020-12-3020101684-1182https://www.scopus.com/inward/record.uri?eid=2-s2.0-78049383899&doi=10.1016%2fS1684-1182%2810%2960058-8&partnerID=40&md5=b398633dddcc0b5359962f3bff3bdd3chttps://scholars.lib.ntu.edu.tw/handle/123456789/536100Background/Purpose: Kikuchi's disease (KD), also known as histiocytic necrotizing lymphadenitis, is a benign and self-limiting disease of unknown etiology that mainly affects young women. There is limited data on the long-term prognosis of patients with KD. Methods: We describe the clinical manifestations and outcomes of 195 patients, diagnosed as having KD at National Taiwan University Hospital from March 1989 to September 2006. Results: All together, 53.3% of our patients presented with tender lymphadenopathy, 37.9% with fever and 16.9% with headache. The most common laboratory findings were elevated erythrocyte sedimentation rate (78.9%), elevated serum lactate dehydrogenase (52.5%), elevated C-reactive protein (38.3%), monocytosis (26.9%), elevated serum alanine aminotransferase (23.3%) and leukopenia (18.9%). A total of 183 patients followed a benign course, with spontaneous resolution of fever and lymphadenopathy. However, 14 patients (14.6%) with follow-up of more than 6 months had clinical recurrence of KD; hence, long-term follow-up is suggested. Five of these patients developed an autoimmune disease, namely, systemic lupus erythematosus (n = 2), Graves' disease (n = 2), or mixed connective tissue disease (n = 1). One patient with recurrent KD died of intracranial hemorrhage due to thrombocytopenia. Conclusion: The prognosis for KD patients is generally optimistic; however, a concurrent autoimmune disease or the risk of developing an autoimmune disease requires careful monitoring. ? 2010 Taiwan Society of Microbiology.[SDGs]SDG3alanine aminotransferase; antibiotic agent; C reactive protein; lactate dehydrogenase; nonsteroid antiinflammatory agent; paracetamol; steroid; adolescent; adult; alanine aminotransferase blood level; antibiotic therapy; arthralgia; article; autoimmune disease; brain hemorrhage; child; chill; clinical feature; coughing; disease association; disease course; epigastric pain; erythrocyte sedimentation rate; female; fever; follow up; Graves disease; headache; human; human tissue; Kikuchi disease; laboratory test; lactate dehydrogenase blood level; leukopenia; long term care; lymph node biopsy; lymphadenopathy; major clinical study; malaise; male; mixed connective tissue disease; monocytosis; night sweat; preschool child; prognosis; rash; recurrent disease; rhinorrhea; school child; sore throat; steroid therapy; systemic lupus erythematosus; thrombocytopenia; university hospital; upper respiratory tract infection; weight reduction; Adolescent; Adult; Autoantibodies; Autoimmune Diseases; Child; Female; Fever; Follow-Up Studies; Histiocytic Necrotizing Lymphadenitis; Humans; Lymphatic Diseases; Male; Middle Aged; Prognosis; Recurrence; Retrospective Studies; Taiwan; Treatment Outcome; Young Adultjournal article10.1016/S1684-1182(10)60058-821075702