Baman, Timir S.Timir S.BamanLange, Dave C.Dave C.LangeIlg, Karl J.Karl J.IlgGupta, Sanjaya K.Sanjaya K.GuptaTZU YU LIUAlguire, CraigCraigAlguireArmstrong, WilliamWilliamArmstrongGood, EricEricGoodChugh, AmanAmanChughJongnarangsin, KritKritJongnarangsinPelosi, FrankFrankPelosiCrawford, ThomasThomasCrawfordEbinger, MatthewMatthewEbingerOral, HakanHakanOralMorady, FredFredMoradyBogun, FrankFrankBogun2023-10-062023-10-062010-07-0115475271https://scholars.lib.ntu.edu.tw/handle/123456789/635974Background: Frequent idiopathic premature ventricular complexes (PVCs) can result in a reversible form of left ventricular dysfunction. The factors resulting in impaired left ventricular function are unclear. Whether a critical burden of PVCs can result in cardiomyopathy has not been determined. Objective: The objective of this study was to determine a cutoff PVC burden that can result in PVC-induced cardiomyopathy. Methods: In a consecutive group of 174 patients referred for ablation of frequent idiopathic PVCs, the PVC burden was determined by 24-hour Holter monitoring, and transthoracic echocardiograms were used to assess left ventricular function. Receiver-operator characteristic curves were constructed based on the PVC burden and on the presence or absence of reversible left ventricular dysfunction to determine a cutoff PVC burden that is associated with left ventricular dysfunction. Results: A reduced left ventricular ejection fraction (mean 0.37 ± 0.10) was present in 57 of 174 patients (33%). Patients with a decreased ejection fraction had a mean PVC burden of 33% ± 13% as compared with those with normal left ventricular function 13% ± 12% (P <.0001). A PVC burden of >24% best separated the patient population with impaired as compared with preserved left ventricular function (sensitivity 79%, specificity 78%, area under curve 0.89) The lowest PVC burden resulting in a reversible cardiomyopathy was 10%. In multivariate analysis, PVC burden (hazard ratio 1.12, 95% confidence interval 1.08 to 1.16; P <.01) was independently associated with PVC-induced cardiomyopathy. Conclusion: A PVC burden of >24% was independently associated with PVC-induced cardiomyopathy. © 2010 Heart Rhythm Society.enPremature ventricular complexes, Ablation, Cardiomyopathyjournal article10.1016/j.hrthm.2010.03.036203480272-s2.0-77953867633https://api.elsevier.com/content/abstract/scopus_id/77953867633