Mouri, AkihiroAkihiroMouriLee, Hsin-JungHsin-JungLeeMamiya, TakayoshiTakayoshiMamiyaAoyama, YukiYukiAoyamaMatsumoto, YurieYurieMatsumotoKubota, HisayoshiHisayoshiKubotaHuang, Wei-JanWei-JanHuangLIH-CHU CHIOUNabeshima, ToshitakaToshitakaNabeshima2020-05-062020-05-062020-03-040007-1188https://scholars.lib.ntu.edu.tw/handle/123456789/490892Hispidulin is a flavonoid isolated from Clerodendrum inerme that was found to inhibit intractable motor tics. Previously, we found that hispidulin attenuates hyperlocomotion and the disrupted prepulse inhibition induced by methamphetamine and N-methyl-d-aspartate (NMDA) receptor antagonists, two phenotypes of schizophrenia resembling positive symptoms. Hispidulin can inhibit COMT, a dopamine-metabolizing enzyme in the prefrontal cortex (PFC) that is important for social interaction. Here, we investigated whether hispidulin would affect social withdrawal, one of the negative symptoms of schizophrenia.enjournal article10.1111/bph.15043321336332-s2.0-85082838622WOS:000523216100001https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082838622&doi=10.1111%2fbph.15043&partnerID=40&md5=e9d8d93b28bd3e41de38dfef184de801