2011-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/650241摘要：全氟碳化合物在環境中不易降解，且已廣泛流布；因其有生物累積之虞，且可能引起發展、免疫、肝臟等不良健康效應，部分全氟碳化合物已於2009年被聯合國列入持久性有機污染物名單，我國環保署也於2010年底公告列管。本研究將針對國人常食用或較易累積全氟碳化合物之14種食品，利用98年度計畫所建立之分析方法，在鹼性消化後以圓盤型吸附劑進行固相萃取，搭配極致液相層析/串聯式質譜儀與同位素稀釋技術分析重要之六種全氟羧酸與兩種全氟磺酸，預計至少進行10個批次。食品中之全氟碳化合物濃度將透過診間對於孕婦進行之飲食型態問卷調查，建立孕婦經由攝食暴露全氟碳化合物之情況，並將此外在暴露對照子計畫二所量測之生物檢體中之含量，提供外在暴露與內在劑量之關連性，以及各化合物可能累積於體內之情形。本暴露量亦將以線性回歸和變異數分析等統計方式與子計畫三、四之孕婦肝功能、新生兒生長指標、幼童之神經發展與甲狀腺功能等健康指標連結，探討可能之暴露劑量−效應關係。透過衛生署之全國膳食調查資料，本研究亦能推估國人每日每公斤體重之攝入量。不論對於易感族群或是一般族群，本研究之全氟碳化合物暴露資料將為未來研究探究可能污染源或政府採取進一步措施之重要依據。<br> Abstract: Perfluorochemicals are persistent and have widely distributed in the environment. They may accumulate in organisms, and may induce adverse effects on development, immune system, and liver. Because of these concerns, the most found perfluorochemicals, perfluorooctyl sulfonate (PFOS) and perfluorooctanoic acid (PFOA), have been included in the Stockholm Convention on Persistent Organic Pollutants by the United Nations in year 2009, and the Taiwan EPA began to regulate these chemicals since the November, 2010.This project will analyze 8 primary perfluorochemicals, including six perfluoroalkyl carboxylates and two perfluoroalkyl sulfonamides, in 14 types of food matrixes that are usually consumed or easily to accumulate perfluorochemicals. Using the developed method at the first year of this project (Year 2009), samples will be digested in alkaline solutions then extracted using disk-type solid-phase extraction and analyzed using ultra-performance liquid chromatography coupled with a triple-quadrupole tandem mass spectrometer with isotope-dilution techniques. The project plans to analyze at least ten batches of food samples.This project will survey pregnant women in clinics of obstetrics and gynecology using questionnaires and build up their dietary patterns. By combining the measured concentrations of perfluorochemicals in food, this project will evaluate the intake of these chemicals of the pregnant women, and compares the external exposure with the internal dose determined in the Project II, which will focus on maternal plasma, cord blood, and human milk. This will provide the information on the bioaccumulation of these chemicals and how to extrapolate the exposure to the body burden. This project will also contrast the individual adverse health effects from the Project III and IV, such as liver functions, the growth indices of newborns, the thyroid functions and neurodevelopment of infants and toddlers. In addition, the concentrations of perfluorochemicals in food can be used to estimate the daily intake of the general population using the Nutrition and Health Survey in Taiwan done by the Department of Health. The information gathered together would be able to estimate the dose-response relationship, and to suggest the tolerable daily intake of perfluorochemicals.全氟碳化合物食物固相萃取極致液相層析/串聯式質譜儀暴露評估perfluorinated chemicalsfoodsolid-phase extractionultra-performance liquid chromatography/tandem mass spectrometryexposure assessment