FENG-JUNG YANGShu K.-H.Chen H.-Y.Chen I.-Y.Lay F.-Y.Chuang Y.-F.Wu C.-S.Tsai W.-C.Peng Y.-S.Hsu S.-P.CHIH-KANG CHIANGWang G.Chiu Y.-L.2021-08-232021-08-2320181742-4933https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049456407&doi=10.1186%2fs12979-018-0120-0&partnerID=40&md5=08db9a73978f307d08c10ea5e709b5d4https://scholars.lib.ntu.edu.tw/handle/123456789/579246Background: Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individuals with normal renal function. Patients with end-stage renal disease (ESRD) exhibit impaired immune function and thus may face higher risk of HCMV-related adverse outcomes. Whether the level of anti-HCMV immune response may be associated with the prognosis of hemodialysis patients is unknown. Results: Among 412 of the immunity in ESRD study (iESRD study) participants, 408 were HCMV seropositive and were analyzed. Compared to 57 healthy individuals, ESRD patients had higher levels of anti-HCMV IgG. In a multivariate-adjusted logistic regression model, the log level of anti-HCMV IgG was independently associated with prevalent coronary artery disease (OR = 1.93, 95% CI = 1.2~ 3.2, p = 0.01) after adjusting for age, sex, hemoglobin, diabetes, calcium phosphate product and high sensitivity C-reactive protein. Levels of anti-HCMV IgG also positively correlated with both the percentage and absolute number of terminally differentiated CD8+ and CD4+ CD45RA+ CCR7- TEMRA cells, indicating that immunosenescence may participate in the development of coronary artery disease. Conclusion: This is the first study showing that the magnitude of anti-HCMV humoral immune response positively correlates with T cell immunosenescence and coronary artery disease in ESRD patients. The impact of persistent HCMV infection should be further investigated in this special patient population. ? 2018 The Author(s).[SDGs]SDG3C reactive protein; calcium phosphate; CD45RA antigen; chemokine receptor CCR7; hemoglobin; immunoglobulin G antibody; adult; antibody titer; Article; atherosclerosis; CD4+ T lymphocyte; CD8+ T lymphocyte; comorbidity; controlled study; coronary artery disease; cytomegalovirus infection; diabetes mellitus; end stage renal disease; female; human; immunosenescence; inflammation; lymphocyte differentiation; major clinical study; male; monocyte; multivariate logistic regression analysis; prevalence; priority journal; sensitivity analysis; T lymphocyte subpopulationjournal article10.1186/s12979-018-0120-02-s2.0-85049456407