臺大公衛學院-流行病學與預防醫學研究所;Chen, Y. C.Y. C.ChenYUNG-LING LEEDong, G. H.G. H.DongLin, K. C.K. C.LinLee, Y. L.Y. L.Lee2018-09-102018-09-102013http://www.scopus.com/inward/record.url?eid=2-s2.0-84874019600&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/382256The aims of our meta-analysis were (i) to quantify the predictability of childhood overweight and obesity on the risk of incident asthma; and (ii) to evaluate the gender difference on this relationship. The selection criteria included prospective cohort paediatric studies which use age- and sex-specific body mass index (BMI) as a measure of childhood overweight and the primary outcome of incident asthma. A total of 1,027 studies were initially identified through online database searches, and finally 6 studies met the inclusion criteria. The combined result of reported relative risk from the 6 included studies revealed that overweight children conferred increased risks of incident asthma as compared with non-overweight children (relative risk, 1.19; 95% confidence interval [CI], 1.03-1.37). The relationship was further elevated for obesity vs. non-obesity (relative risk, 2.02; 95% CI, 1.16-3.50). A dose-responsiveness of elevated BMI on asthma incidence was observed (P for trend, 0.004). Obese boys had a significantly larger effect than obese girls (relative risk, boys: 2.47; 95% CI, 1.57-3.87; girls: 1.25; 95% CI, 0.51-3.03), with significant dose-dependent effect. Proposed mechanisms of gender difference could be through pulmonary mechanics, sleep disordered breathing and leptin. Further research might be needed to better understand the exact mechanism of gender difference on the obesity-asthma relationship. ? 2012 The Authors. obesity reviews ? 2012 International Association for the Study of Obesity.114 bytestext/htmlBody weight; Children; Cohort studies; Incidence; Respiratory tract disease[SDGs]SDG3[SDGs]SDG5leptin; asthma; body mass; body weight; childhood obesity; disease predisposition; follow up; human; incidence; lung mechanics; meta analysis; review; risk factor; sex difference; sleep disordered breathing; systematic review; Asthma; Body Mass Index; Child; Cohort Studies; Comorbidity; Female; Humans; Incidence; Male; Obesity; Overweight; Prospective Studies; Risk Factors; Severity of Illness Index; Sex Factorsjournal article10.1111/j.1467-789X.2012.01055.x