Pfaller M.A.Diekema D.J.Colombo A.L.Kibbler C.Ng K.P.Gibbs D.L.Newell V.A.Finquelievich J.Tiraboschi N.Ellis D.Frameree D.van den Abeele A.Senterre J.-M.Colombo A.Rennie R.Sanche S.Hu B.Xu Y.Zhang Y.Zhong N.S.Rivas P.Restrepo A.Bedout C.Vega R.Mendez M.Mallatova N.Dobiasova S.Ayabaca J.Zurita J.Mallie M.Candolfi E.Fegeler W.Haase A.Rodloff G.Bar W.Czaika V.Petrikos G.Puskás E.Doczi I.Gyula M.Nikolova R.Banerjee U.Keller N.Tullio V.Carlo Schito G.Fortina G.Piero Testore G.D'Antonio D.Scalise G.Martino P.Manno G.Peng K.Alpuche C.Santos J.Rodriguez Noriega E.Zaidi M.Meis J.F.G.M.Lingaas E.Dzierzanowska D.Pawliszyn W.Luz Martins M.Albuquerque L.Rosado L.Velho R.Amorim J.Ilina V.N.Kretchikova O.I.Klyasova G.A.Rozanova S.M.Multykh I.G.Klimko N.N.Agapova E.D.Dmitrieva N.V.Al-Rasheed A.M.Trupl J.Langsadl L.Vaculikova A.Helena H.Roditi D.Hoosen A.Crewe-Brown H.H.Janse van Rensburg M.N.Duse A.Lee K.Kim M.-N.del Palacio A.Sanchez-Sousa A.Bille J.Muhlethaler K.SHAN-CHWEN CHANGWang J.-H.Vorachit M.Gur D.Korten V.Paul J.Jones B.Kate Gould F.Kibbler C.Weightman N.Gould I.M.Ashbee R.Barnes R.Vazquez J.Chan E.Larone D.Jo Baron E.Ghannoum M.A.Rinaldi M.Hazen K.Foraker E.Reyes H.Santiago A.2020-12-302020-12-3020060095-1137https://www.scopus.com/inward/record.uri?eid=2-s2.0-33947634712&doi=10.1128%2fJCM.00863-06&partnerID=40&md5=ceb1eb60138f10aa15429bd05a8f37f7https://scholars.lib.ntu.edu.tw/handle/123456789/536005Candida rugosa is a fungus that appears to be emerging as a cause of infection in some geographic regions. We utilized the extensive database of the ARTEMIS DISK Antifungal Surveillance Program to describe the geographic and temporal trends in the isolation of C. rugosa from clinical specimens and the in vitro susceptibilities of 452 isolates to fluconazole and voriconazole. C. rugosa accounted for 0.4% of 134,715 isolates of Candida, and the frequency of isolation increased from 0.03% to 0.4% over the 6.5-year study period (1997 to 2003). C. rugosa was most common in the Latin American region (2.7% versus 0.1 to 0.4%). Decreased susceptibility to fluconazole (40.5% susceptible) was observed in all geographic regions; however, isolates from Europe and North America were much more susceptible (97 to 100%) to voriconazole than those from other geographic regions (55.8 to 58.8%). C. rugosa was most often isolated from blood and urine in patients hospitalized at the Medical and Surgical inpatient services. Notably, bloodstream isolates were the least susceptible to both fluconazole and voriconazole. C. rugosa should be considered, along with the established pathogens Candida krusei and Candida glabrata, as a species of Candida with reduced susceptibility to the azole antifungal agents. Copyright ? 2006, American Society for Microbiology. All Rights Reserved.[SDGs]SDG3fluconazole; voriconazole; antifungal agent; fluconazole; pyrimidine derivative; triazole derivative; voriconazole; article; Candida glabrata; Candida krusei; Candida rugosa; controlled study; drug sensitivity; fungus isolation; geographical variation (species); hospital patient; in vitro study; nonhuman; priority journal; South and Central America; antibiotic resistance; Candida; candidiasis; classification; drug effect; health; health survey; human; microbiology; Candida; Candida glabrata; Candida rugosa; Fungi; Issatchenkia orientalis; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Population Surveillance; Pyrimidines; Triazoles; World Healthjournal article10.1128/JCM.00863-0617021085