Carlson P.DEvans M.EANGELA YU-CHEN LINStrobel E.JLucks J.B.2022-11-162022-11-16201800928674https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054162520&doi=10.1016%2fj.cell.2018.09.024&partnerID=40&md5=b647701225acd758c207b65859440338https://scholars.lib.ntu.edu.tw/handle/123456789/625604Chemical probing coupled to high-throughput sequencing offers a flexible approach to uncover many aspects of RNA structure relevant to its cellular function. With a wide variety of chemical probes available that each report on different features of RNA molecules, a broad toolkit exists for investigating in vivo and in vitro RNA structure and interactions with other molecules. Chemical probing coupled to high-throughput sequencing offers a flexible approach to uncover many aspects of RNA structure relevant to its cellular function. With a wide variety of chemical probes available that each report on different features of RNA molecules, a broad toolkit exists for investigating in vivo and in vitro RNA structure and interactions with other molecules. © 2018 Elsevier Inc.cell function; DNA probe; high throughput sequencing; in vitro study; in vivo study; RNA structure; short survey; animal; biology; conformation; human; procedures; sequence analysis; software; ultrastructure; RNA; Animals; Computational Biology; High-Throughput Nucleotide Sequencing; Humans; Nucleic Acid Conformation; RNA; Sequence Analysis, RNA; Softwareshort survey10.1016/j.cell.2018.09.024302901452-s2.0-85054162520