Clinical manifestations and risk factors for mortality of patients with severe influenza during the 2016

WANG-DA LIUYeh C.-Y.Shih M.-C.WANG-HUEI SHENG2021-02-262021-02-2620201201-9712https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085147379&doi=10.1016%2fj.ijid.2020.04.013&partnerID=40&md5=cc35477545631bad7b1e098bd6cb7852https://scholars.lib.ntu.edu.tw/handle/123456789/549615Objectives: Influenza remains a crucial transmissible disease from community. We aim to identify risk factors associated with mortality among hospitalized patients with severe influenza. Methods: We retrospectively reviewed medical records of adult patients with laboratory-confirmed severe influenza at a medical center between January 2016 and December 2018. The primary outcome was 30-day all-cause mortality. Results: Totally 96 patients were enrolled, with 73 patients in the influenza A group and 23 in the influenza B group. Eighteen (18.8%) deaths occurred within 30 days of hospitalization, including 8 (11%) and 10 (43.5%) of each group. In multivariable Cox regression analysis, factors associated with mortality were underlying diseases of liver cirrhosis (adjusted hazard ratio [AHR], 3.94; 95% CI, 1.07–14.45) and rheumatologic diseases (AHR, 7.45; 95% CI, 2.34–23.69) and the diagnosis of influenza B (AHR, 4.33; 95% CI, 1.68–11.13). Conclusions: Clinician should early identify high-risk population and warning signs of severe influenza. Our results support the policy of quadrivalent influenza vaccination because influenza B could be associated with high mortality. ? 2020 The Author(s)[SDGs]SDG3adult; aged; all cause mortality; Article; clinical feature; cohort analysis; controlled study; coronary artery disease; coughing; diarrhea; dyspnea; extracorporeal oxygenation; female; fever; headache; hospitalization; human; influenza A; influenza B; liver cirrhosis; major clinical study; malaise; male; malignant neoplasm; mental disease; outcome assessment; retrospective study; rheumatic disease; rhinorrhea; risk factor; survival rate; thorax pain; complication; influenza; middle aged; mortality; proportional hazards model; risk factor; season; influenza vaccine; Aged; Cohort Studies; Female; Hospitalization; Humans; Influenza Vaccines; Influenza, Human; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; SeasonsClinical manifestations and risk factors for mortality of patients with severe influenza during the 2016–2018 seasonjournal article10.1016/j.ijid.2020.04.013322895622-s2.0-85085147379