CHUN-YU WUKUANG-CHENG CHANYA-JUNG CHENGYU-CHANG YEHChien, Chiang-TingChiang-TingChien2019-09-042019-09-042015-12-111466-609Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84956815406&doi=10.1186%2fs13054-015-1135-y&partnerID=40&md5=ca0a30640765fb09576d2a0127474213https://scholars.lib.ntu.edu.tw/handle/123456789/417354Fluid resuscitation is an indispensable procedure in the acute management of hemorrhagic shock for restoring tissue perfusion, particularly microcirculation in splanchnic organs. Resuscitation fluids include crystalloids, hypertonic saline (HTS), and synthetic colloids, and their selection affects the recovery of microcirculatory blood flow and reactive oxygen species (ROS) formation, which is often evident in the kidney, following reperfusion. In this study, the effects of acute resuscitation with 0.9% saline (NS), 3% HTS, 4% succinylated gelatin (GEL), and 6% hydroxyethyl starch (HES) 130/0.4 were compared in a hemorrhagic shock rat model to analyze restoration of microcirculation among various splanchnic organs and the gracilis muscle and reperfusion-induced renal ROS formation.enjournal article10.1186/s13054-015-1135-y266519942-s2.0-84956815406WOS:000366348700001https://api.elsevier.com/content/abstract/scopus_id/84956815406