Wu H.C.Lin J.Y.Hsieh S.Y.Wang T.W.JUI-SHENG SUN2020-02-072020-02-0720151680-0737https://www.scopus.com/inward/record.uri?eid=2-s2.0-84914814296&doi=10.1007%2f978-3-319-11128-5_2&partnerID=40&md5=bed293198616d8afb91391a09a6110dahttps://scholars.lib.ntu.edu.tw/handle/123456789/455315Hyperthermia for the treatment of resistant tumors has been reported with promising results. Repeated treatment times and applicable for many kinds of cancers are the potential benefits of hyperthermia. Of note is that the success of intracellular hyperthermia is largely dependent on the development of an adequate heat mediator. In this work, we have successfully developed an intracellular hyperthermia system using magnetic hydroxyapatite (mHap) nanocrystals as a thermoseed. After surface modification, poly (ethylene glycol) (PEG) and hyaluronic acid (HA) modified mHap nanocrystals could not only be localized and accumulated in cancer cells, but also efficiently taken up by targeted tumor cells via HA receptor mediated endocytosis process. Furthermore, these Hap-based magnetic nanocrystals may also serve as a tracer for the diagnostic contrast agent under MRI and a drug delivery carrier for therapeutic applications in cancer therapy in vitro and in vivo. ? Springer International Publishing Switzerland 2015.[SDGs]SDG3Biochemical engineering; Biomedical engineering; Diagnosis; Diseases; Drug delivery; Hyaluronic acid; Molecular biology; Nanocrystals; Polyethylene glycols; Surface treatment; Tumors; Contrast agent; Drug delivery carrier; Hyperthermia; Hyperthermia systems; Magnetic nanocrystals; Potential benefits; Receptor-mediated endocytosis; Therapeutic Application; Hyperthermia therapyconference paper10.1007/978-3-319-11128-5_22-s2.0-84914814296