Shin C.-SBaldeck P.LNie Y.-MLee Y.-HLin Z.-DChiang C.-CLin C.-L.CHOW-SHING SHIN2021-08-052021-08-05202118761070https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104111189&doi=10.1016%2fj.jtice.2021.03.028&partnerID=40&md5=f312156ceaa366686605719b8ee46356https://scholars.lib.ntu.edu.tw/handle/123456789/576128Recent developments in 3D micromixers promise to accomplish satisfactory mixing for applications in microchemical process, biomicrofluidic analyses, μ-TAS, etc. However, the complicated 3D architecture employed to ensure thorough mixing might reduce fluid circulation due to the space for fluid flowing becomes narrow. In this study, we developed a single 3D multi-manifold micromixer composed of a double-Archimedes-screw for rapidly mixing within a short distance. Archimedes screw is well known for its fluid circulation under stable flow. The mixing strategy is based on split-and-recombination for increasing the interfacial area, and the 3D flow rotation for generating omnidirectional momentum-changes during the fluid propagation. With the spiral conformation, the Archimedes-screw micromixer (ASM) can substantially enhance fluid circulation. Numerical simulations used to help to design the optimal screw-turn show that satisfactory mixing efficiency can achieve at the distance of approximately twice the microchannel width. The ASM characteristics, such as pressure loss, ratio of cross-sections, and Reynolds number (Re) were evaluated. Experimental demonstration by an ASM fabricated by two-photon stereolithography showed mixing result in good agreement with the simulation findings. ? 2021 Taiwan Institute of Chemical EngineersMixers (machinery); Reynolds number; Screws; Archimedes screws; Design and evaluations; Experimental demonstrations; Fluid circulation; Interfacial areas; Mixing efficiency; Split and recombinations; Two-photon stereolithography; Mixing[SDGs]SDG3[SDGs]SDG9journal article10.1016/j.jtice.2021.03.0282-s2.0-85104111189