Hung-Lin ChenHsiu-Yin ChiangDavid Ray ChangChi-Fung ChengCharles C. N. WangTZU-PIN LUChien-Yueh LeeAmrita ChattopadhyayYu-Ting LinChe-Chen LinPei-Tzu YuChien-Fong HuangChieh-Hua LinHung-Chieh YehI-Wen TingHuai-Kuang TsaiERIC YAO-YU CHUANGAdrienne TinFuu-Jen TsaiChin-Chi Kuo2024-12-032024-12-032024-10-29https://scholars.lib.ntu.edu.tw/handle/123456789/723501Current genome-wide association studies (GWAS) for kidney function lack ancestral diversity, limiting the applicability to broader populations. The East-Asian population is especially under-represented, despite having the highest global burden of end-stage kidney disease. We conducted a meta-analysis of multiple GWASs (n = 244,952) on estimated glomerular filtration rate and a replication dataset (n = 27,058) from Taiwan and Japan. This study identified 111 lead SNPs in 97 genomic risk loci. Functional enrichment analyses revealed that variants associated with F12 gene and a missense mutation in ABCG2 may contribute to chronic kidney disease (CKD) through influencing inflammation, coagulation, and urate metabolism pathways. In independent cohorts from Taiwan (n = 25,345) and the United Kingdom (n = 260,245), polygenic risk scores (PRSs) for CKD significantly stratified the risk of CKD (p < 0.0001). Further research is required to evaluate the clinical effectiveness of PRSCKD in the early prevention of kidney disease.en[SDGs]SDG2[SDGs]SDG3journal article10.1038/s41467-024-53516-739472450