2011-08-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/655282摘要：本研究將開發新一代之奈米碳管藥物載體，希望透過奈米碳管特殊的場致發射能力、光學性質和熱傳導性，並合併光感藥物，能同時於腫瘤部位產生電穿孔、光動力治療以及熱治療三種機制，達到高效能藥物傳輸結合光動力治療與熱治療之多功能性，完成高效率且雙重毒殺癌細胞之效果。主要方式為，先於腫瘤位置利用電刺激，使癌細胞產生電穿孔效應，令藥物能大量累積於腫瘤達到高效能藥物傳輸之後，再以特定波長之紅光雷射照射腫瘤處，進行光動力治療；並輔以奈米碳管吸收光能後迅速升溫且快速傳導之特性，更進一步地利用高溫殺死癌細胞，達到光動力治療以及高溫熱治療之雙重目標。<br> Abstract: Carbon nanotubes (CNTs) have been proposed and actively explored as multifunctional innovative carriers for drug delivery. This project presents a new modality for cell electro-permeabilisation based on the use of CNTs and external static electric fields to achieve highly drug delivery efficiency. Besides, CNTs are unique materials that absorb infrared (IR) radiation in the special spectral window where body tissues are most transparent. Absorbed IR promotes molecular oscillation leading to efficient heating of the surrounding environment. By using these characteristics of CNTs, we conjugate photosensitizers (PS) on chemically functionalized single-walled carbon nanotubes (f-SWNTs) to combine photodynamic therapy and hyperthermia for killing cancer cells specifically and effectively. Thus, CNT complex drug delivery is promising for improving the efficacy of drug delivery and treatment to decrease side effects for future cancer therapy.奈米碳管電穿孔光動力治療熱治療carbon nanotubeselectro-permeabilisationphotodynamic therapyhyperthermia