陳保中2006-07-252018-06-292006-07-252018-06-291999-07-31http://ntur.lib.ntu.edu.tw//handle/246246/4937近二十年來隨著社會的變遷造成環境的改 變，生殖醫學相關科技的日益進步，國際上對環境 職業性危害因子可能造成生殖上的問題廣為關 注，其中以年齡25 至34 歲的高生育群婦女成長最 多。在評估生殖能力方面又以受孕前所需時間（time to pregnancy ）為其新興工具，但是台灣至今尚無此 相關參考標準。本研究係繼台灣省家庭計畫研究所 於1997 年「臺灣地區不孕盛行狀況調查研究報告」 之後續研究，為建立全台灣地區婦女生育力之平均 標準曲線，以台灣地區婦女為對象進行抽樣，排除 外島及山地鄉地區，蒐集婦女相關生育資料、影響 生殖之疾病史，俾建立台灣地區婦女之生育力參考 標準，並應用於相關職業性生殖危害的比較依據， 以及其他相關計畫工作執行之參考。經由9143 個 案中抽樣取601 名婦女進行訪視，實際訪察408 人，完訪241 名, 完訪率約59.1%。未完訪者多因 遷移緣故，拒訪者佔24 名（5.9%），共取得681 孕次，其中全部有效孕次計608 次，近14 年來之 孕次則計有588 次。經Cox Model 分析，整體而言 各可能影響因子與隨時間受孕累積比例並無顯著 相關。在3 個月內累積受孕比為60.0%，至六個月 為75.9%，至九個月為81.8%，至一年為89.8%， 一年以內未懷孕者達10.2%。第二次以上懷孕者較 初次懷孕之受孕能力比為低0.9178 （95% CI=0.77-1.09 ），與泰國地區情況相似。而整體受孕累積比 則與國際各國接近，尤其是英國一般族群為對象之 研究結果。The objective of this study is to construct the reference curve of fecundibility in term of waiting time to pregnancy in the general population of Taiwan. This study was a retrospective study. We used data from a marriage cohort of the infertility of Taiwan conducted by Institute of Taiwan family planning in 1996. The population included 9143 couples spread in Taiwan and married in April 1990. We sampled 601 couples and interviewed them using a structured questionnaire. We visited 408 couples from 1998 to 1999. 241 women (59%) completed interviews and 588 pregnancies were analyzed with Cox regression model. Women were categorized and analyzed according to their waiting time to pregnancy that was defined at least one month and above. The analysis excluded the pregnancies delivered more than 14 years ago to reduce recall bias, and those without the information of time to pregnancy. Compared with the waiting time that women tried to conceive before each pregnancy, the cumulative percent was 56% in 3 months, 75.9% in 6 months, 81.8% in 9 months, and 89.8 % in one year. 10.2% pregnancies in total were not conceived before one year, and the waiting time to conception before each pregnancy of the women in Taiwan was similar with the published data in Asian and European countries. The fecundibilty curve of time to pregnancy in Taiwan general population can be used to estimate the risk of subfecundibility of specific occupational exposures. And it can also be used to compare the fecundibility with other races or countries.application/pdf73016 bytesapplication/pdfzh-TW國立臺灣大學公共衛生學院職業醫學與工業衛生研究所受孕所需時間生育力生殖危害Time to pregnancyFecundibilityReproductive hazardsreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/4937/1/882314B002267.pdf