The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population

Lin, Chien-YuChien-YuLinLee, Hui-LingHui-LingLeeCHING-WAY CHENWang, ChikangChikangWangSung, Fung-ChangFung-ChangSungTA-CHEN SU2023-06-282023-06-282023-05-1718687075https://scholars.lib.ntu.edu.tw/handle/123456789/633167Adiponectin is a key protein produced in adipose tissue, with crucial involvement in multiple metabolic processes. Di-(2-ethylhexyl) phthalate (DEHP), one of the phthalate compounds used as a plasticizer, has been shown to decrease adiponectin levels in vitro and in vivo studies. However, the role of angiotensin I-converting enzyme (ACE) gene polymorphism and epigenetic changes in the relationship between DEHP exposure and adiponectin levels is not well understood.en5mdC/dG; Adiponectin; DEHP (di-(2-ethylhexyl) phthalate); Epigenetic modifications; Glucose homeostasis; MEHP (mono(2-ethylhexyl) phthalate)[SDGs]SDG3The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese populationjournal article10.1186/s13148-023-01502-z371986932-s2.0-85159942304https://api.elsevier.com/content/abstract/scopus_id/85159942304