2016-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/689722摘要：聚胺酯(PU)類材料具有優異的彈性與生物相容性，可經由分子設計使其具有雙性鏈段而在水相中 自乳化聚合而成水性聚胺酯，亦可選用可分解的軟鏈段製備水性生物可降解性聚胺酯(waterborne biodegradable polyurethane, WBDPU)，其生物分解特性與水性製程有利於生物醫學之應用。目前我們 已初步合成出具有溫度感應及形狀記憶特性之PU 材料，然而因生醫領域需更仿生及具智慧性之材料 以增加生物相容性與功能性，我們希望結合過去PU 合成與生醫材料開發之經驗，設計出適合人體應 用之智慧性WBDPU，並結合水性加工技術進行成型。此次提出之三年期計畫擬建立新穎WBDPU 配 方，並針對其基本物化特性、成膠機制、形狀記憶機制及生醫應用性進行深入的探討。第一年重點在 材料合成與分析，調整可降解聚酯軟鏈段的種類及組合比例，初步評估其物化特性與配方材料之體外 /體內生物相容性，並分析受環境感應形成水膠之流變學特性，以及形狀記憶之能力。第二年重點在優 化水膠與形狀記憶材料合成配方與參數，並分析其成型機制與作用原理，接著再以水性加工技術(三維 列印及靜電紡絲)製成支架並確認在加工後智慧性仍得以維持。第三年則延續前兩年之成果進行 WBDPU 水膠與支架細胞測試及動物實驗，並透過此三年所建立的物化特性與體內外實驗等分析結 果，瞭解影響WBDPU 智慧性之物化機制與設計準則，並建立不同生醫應用之最適化原料配方。<br> Abstract: Polyurethanes are commonly used as biomaterials due to their good biocompatibility and elastomeric properties. In recent years, waterborne biodegradable polyurethanes (WBDPU) have been synthesized by biodegradable soft segments and water process. The biodegradability and water processing of WBDPU can be advantageous for biomedical applications. Our recent studies have indicated that some formulae of synthetic WBDPU showed the temperature responsive gelling behavior or shape memory properties. These unique characteristics of WBDPU materials are beneficial for biomedical applications. We hope to utilize our development experiences of WBDPU to design a category of smart materials that are suitable for use in the human body. Therefore, we propose this three-year project to develop different formulae of WBDPU by changing different types and ratios of the biodegradable macrodiols, to establish the physico-chemical properties, mechanism of gel formation, and shape memory properties, and to evaluate the therapeutic potential in biomedical fields. In the first year, we will focus on materials preparation and analysis, including WBDPU synthesis, physico-chemical characterization, biocompatibility and degradation evaluation, as well as rheological measurement and shape memory testing. In the second year, we will concentrate on optimization of the WBDPU formulae for temperature responsive hydrogels and shape memory elastomers. The mechanisms for hydrogel formation and shape memory properties in WBDPU will be examined. After that we will analyze the functional properties of the WBDPU scaffolds after fabrication by three-dimensional printing or electrospinning. In the third year, we will perform the in vivo evaluation for the hydrogels or shape memory elastomers. Through this three-year project, we will establish various hydrogel forming and shape memory mechanisms to optimize WBDPU preparation for a wide range of biomedical applications.水性生物可降解聚胺酯感應性水膠形狀記憶彈性體智慧性材料