Li, ShimingShimingLiLin, Yi-ChinYi-ChinLinHo, Chi-TangChi-TangHoLin, Ping-YiPing-YiLinSuzawa, MichikoMichikoSuzawaWang, Hsin-ChiehHsin-ChiehWangCHING-LIANG CHUChen, Der-YuanDer-YuanChenLIN-CHI CHEN2023-01-102023-01-102014-051567-5769https://scholars.lib.ntu.edu.tw/handle/123456789/627090It has been reported that gold lotion (GL), a formulated product made from the peels of six citrus fruits, has many pharmacological properties, such as anti-tumor, antioxidant, and anti-inflammatory activities. In this study, we investigated the immunomodulatory effect of GL on lipopolysaccharide (LPS) stimulated mouse bone marrow-derived DC maturation and function. Our experimental results have shown that GL significantly impaired the pro-inflammatory cytokine and chemokine secretion, suppressed the expression of major histocompatibility complex class I/II and costimulatory molecules (CD40, CD80 and CD86), increased phagocytic capacity, and reduced propensity to stimulate the autologous CD4(+) and CD8(+) T cell proliferation of LPS-induced DCs. Furthermore, we found that oral administration of GL attenuated the 2,4-Dinitro-1-fluorobenzene induced contact hypersensitivity (CHS) in animal models. Subsequently, our molecular mechanism studies showed that GL interfered with LPS-induced MAPK-JNK, p38 phosphorylation and nuclear translocation of NF-κB p65. In an essence, these findings are the first report to provide new insight in the immunopharmacological role of GL in terms of its effects on DC.enCitrus; Contact hypersensitivity (CHS); Dendritic cells; Peels; T cellsjournal article10.1016/j.intimp.2014.02.005245660932-s2.0-84895535344WOS:000336337900002https://scholars.lib.ntu.edu.tw/handle/123456789/384210http://www.scopus.com/inward/record.url?eid=2-s2.0-84895535344&partnerID=MN8TOARS