Huang, Huey-ChungHuey-ChungHuangPO-YUAN CHANGChang, KarenKarenChangChen, Chao-YuChao-YuChenCHUNG-WU LINJYH-HORNG CHENCHUNG-YUAN MOUZEE-FEN CHANGFU-HSIUNG CHANG2020-12-282020-12-282009-09-211423-0127https://scholars.lib.ntu.edu.tw/handle/123456789/533911https://www.scopus.com/inward/record.uri?eid=2-s2.0-70350624421&doi=10.1186%2f1423-0127-16-86&partnerID=40&md5=2d509c271a8c6d164801b129229ea2ddApplication of superparamagnetic iron oxide nanoparticles (SPIOs) as the contrast agent has improved the quality of magnetic resonance (MR) imaging. Low efficiency of loading the commercially available iron oxide nanoparticles into cells and the cytotoxicity of previously formulated complexes limit their usage as the image probe. Here, we formulated new cationic lipid nanoparticles containing SPIOs feasible for in vivo imaging.en[SDGs]SDG31,2 dioleoyl 3 trimethylammoniopropane; ferric ferrocyanide; macrogol 2000; phosphatidylethanolamine; rhodamine; superparamagnetic iron oxide nanoparticle; 1,2 dioleoyl 3 trimethylammoniopropane; 1,2 distearyl 3 sn phosphatidylethanolamine; contrast medium; lipid; macrogol 2000; magnetic nanoparticle; nuclear magnetic resonance imaging agent; phosphatidylethanolamine; polymer; superparamagnetic iron oxide nanoparticle; unclassified drug; 1,2 dioleoyloxy 3 (trimethylammonium)propane; 1,2-dioleoyloxy-3-(trimethylammonium)propane; cation; contrast medium; diagnostic agent; dioleoyl phosphatidylethanolamine; ferric ion; ferric oxide; macrogol derivative; metal nanoparticle; monounsaturated fatty acid; phosphatidylethanolamine; polyethylene glycol distearoylphosphatidylethanolamine; polyethylene glycol-distearoylphosphatidylethanolamine; quaternary ammonium derivative; animal experiment; animal model; article; cell differentiation; controlled study; cytotoxicity; flow cytometry; fluorescence microscopy; human; human cell; laser Doppler flowmetry; light scattering; mechanical probe; micelle; mouse; nerve cell; nonhuman; nuclear magnetic resonance imaging; particle size; priority journal; surface charge; tumor cell; tumor growth; zeta potential; animal cell; Article; cancer cell line; cell growth; contrast enhancement; HeLa cell line; hydrophobicity; imaging; in vivo study; nanoprobe; nerve cell differentiation; nuclear magnetic resonance scanner; adenocarcinoma; animal; Bagg albino mouse; colorectal tumor; drug effect; evaluation; feasibility study; HeLa cell; male; neuroblastoma; pathology; prostate tumor; synthesis; transplantation; tumor cell line; Mus; Adenocarcinoma; Animals; Cations; Cell Differentiation; Cell Line, Tumor; Colorectal Neoplasms; Contrast Media; Fatty Acids, Monounsaturated; Feasibility Studies; Ferric Compounds; Hela Cells; Humans; Hydrophobicity; Magnetic Resonance Imaging; Male; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Micelles; Neuroblastoma; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Prostatic Neoplasms; Quaternary Ammonium Compounds; Rhodamines10.1186/1423-0127-16-86197725522-s2.0-70350624421