Fan, Tian-SinTian-SinFanLiu, Sam Chi-HaoSam Chi-HaoLiuRUEY-MEEI WU2023-08-252023-08-252021-11-162075-1729https://scholars.lib.ntu.edu.tw/handle/123456789/634689Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement.enLewy body; Parkinson disease; SNCA; alpha-synuclein; biomarker; cognition; dementia; genetic; neurodegeneration; non-motor symptomjournal article10.3390/life11111239348331152-s2.0-85119701300https://api.elsevier.com/content/abstract/scopus_id/85119701300