A fully integrated hepatitis B virus DNA detection SoC based on monolithic polysilicon nanowire CMOS process

SHEY-SHI LUCHIH-TING LIN2018-09-102018-09-102012http://scholars.lib.ntu.edu.tw/handle/123456789/372316Polysilicon nanowire (poly-Si NW) based biosensor is integrated with the wireless acquisition circuits in a standard CMOS SoC for the first time. To improve detection quality, a chopper DDA-based analog front-end with features of low noise, high CMRR, and rail-to-rail input range is implemented. Additional temperature sensor is also included to compensate temperature drift of the biosensor. The results indicate that the detection limit is as low as 10fM. The capability to distinguish one base-pair mismatched DNAs is also demonstrated. ? 2012 IEEE.[SDGs]SDG3Analog front-end; CMOS processs; Detection limits; DNA detection; Fully integrated; Hepatitis B virus; Low noise; Mismatched DNA; Polysilicon nanowires; Rail-to-rail input; Standard CMOS; Temperature drifts; Biosensors; Nanowires; Nucleic acids; Polysilicon; Viruses; VLSI circuits; CMOS integrated circuitsA fully integrated hepatitis B virus DNA detection SoC based on monolithic polysilicon nanowire CMOS processjournal article10.1109/VLSIC.2012.6243821