Zubair, NihaNihaZubairGraff, MariaelisaMariaelisaGraffLuis Ambite, JoseJoseLuis AmbiteBush, William SWilliam SBushKichaev, GlebGlebKichaevLu, YingchangYingchangLuManichaikul, AniAniManichaikulSheu, Wayne H-HWayne H-HSheuAbsher, DevinDevinAbsherAssimes, Themistocles LThemistocles LAssimesBielinski, Suzette JSuzette JBielinskiBottinger, Erwin PErwin PBottingerBuzkova, PetraPetraBuzkovaLEE-MING CHUANGChung, Ren-HuaRen-HuaChungCochran, BarbaraBarbaraCochranDumitrescu, LoganLoganDumitrescuGottesman, OmriOmriGottesmanHaessler, Jeffrey WJeffrey WHaesslerHaiman, ChristopherChristopherHaimanHeiss, GerardoGerardoHeissHsiung, Chao AChao AHsiungHung, Yi-JenYi-JenHungHwu, Chii-MinChii-MinHwuJYH-MING JIMMY JUANGLe Marchand, LoicLoicLe MarchandLee, I-TeI-TeLeeLee, Wen-JaneWen-JaneLeeLin, Li-AnLi-AnLinLin, DanyuDanyuLinLin, Shih-YiShih-YiLinMackey, Rachel HRachel HMackeyMartin, Lisa WLisa WMartinPasaniuc, BogdanBogdanPasaniucPeters, UlrikeUlrikePetersPredazzi, IreneIrenePredazziQuertermous, ThomasThomasQuertermousReiner, Alex PAlex PReinerRobinson, JenniferJenniferRobinsonRotter, Jerome IJerome IRotterRyckman, Kelli KKelli KRyckmanSchreiner, Pamela JPamela JSchreinerStahl, EliEliStahlTao, RanRanTaoTsai, Michael YMichael YTsaiWaite, Lindsay LLindsay LWaiteTZUNG-DAU WANGBuyske, StevenStevenBuyskeIda Chen, Yii-DerYii-DerIda ChenCheng, IonaIonaChengCrawford, Dana CDana CCrawfordLoos, Ruth J FRuth J FLoosRich, Stephen SStephen SRichFornage, MyriamMyriamFornageNorth, Kari EKari ENorthKooperberg, CharlesCharlesKooperbergCarty, Cara LCara LCarty2023-02-082023-02-082016-12-150964-6906https://scholars.lib.ntu.edu.tw/handle/123456789/627696Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown. We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians. The majority of signals found in these groups generalize to European Americans. While we uncovered signals unique to racial/ethnic populations, we also observed systematically consistent lipid associations across these groups. In African Americans, we identified three novel signals associated with HDL-C (LPL, APOA5, LCAT) and two associated with LDL-C (ABCG8, DHODH). In addition, using this population, we refined the location for 16 out of the 58 known MetaboChip lipid loci. These results can guide tailored screening efforts, reveal population-specific responses to lipid-lowering medications, and aid in the development of new targeted drug therapies.enGENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; LINKAGE DISEQUILIBRIUM; VARIANTS; METAANALYSIS; TRIGLYCERIDE; ANNOTATION; HAPLOTYPES; TRAITS; RISK[SDGs]SDG3journal article10.1093/hmg/ddw358284268902-s2.0-85016010547WOS:000397063900019https://api.elsevier.com/content/abstract/scopus_id/85016010547