Lee, HYHYLeeChiang, PYPYChiangWu, HJHJWuWang, TYTYWangYang, TCTCYangCheng, Wei-ChiehWei-ChiehChengLEE-CHIANG LOWEI-SSU LIAO2022-12-152022-12-1520222574-0970https://scholars.lib.ntu.edu.tw/handle/123456789/626478Herein, we adopt a bottom-up approach to achieve the first one-pot synthesis of azido-functionalized carbon dots (CDs) through a unique glucose-azidoamine two-component recipe. The azido content on CDs can be well-tuned by partially replacing the azidoamine with a methoxyamine diluent during the synthesis. Task-oriented payloads could then be conveniently connected to the azido-functionalized CDs through click chemistry. As a demonstration, we exploit strain-promoted alkyne-azide cycloaddition to obtain folate-decorated CDs, which can selectively display fluorescence in tumor cell lines with elevated levels of folate receptors. This facile production of azido-functionalized CDs should provide huge advantages for future applications.fluorescence; metal-free; click chemistry; folate; cellular imaging; QUANTUM DOTS; CLICK; FLUORESCENCE; MECHANISM[SDGs]SDG3journal article10.1021/acsanm.2c017662-s2.0-85135082506WOS:000818738800001https://api.elsevier.com/content/abstract/scopus_id/85135082506