2018-01-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/653880摘要：今年諾貝爾化學獎頒給了用於解析蛋白質結構之冷凍電子顯微鏡技術，可見蛋白質體學與結構生物學之重要，尤其是冷凍電鏡，克服了傳統X-ray與NMR的諸多限制，正是當前結構生物學之首要利器，我們將建立生物環境與冷凍電鏡研究團隊，提升目標蛋白質結構解析度，並利用&#63756;米金&#63993;子標定方法與微流腔體等技術&#63789;追蹤細胞內蛋白質交互作用，將有助於了解蛋白質訊息傳遞與神經細胞生長退化之關聯，輔助人類疾病治療及藥物設計開發，期望此成為醫藥界的福音為全人類之福祉帶來助益。<br> Abstract: This year`s Nobel Prize in Chemistry was awarded for the analysis of protein structures by cryo-electron microscopy (cryo-EM), showing the importance of proteomics and structural biology. Cryo-EM had overcome many limitations of traditional methods such as X-ray and NMR, and it is arising as the main stream of the current structural biology. In this project, we will establish the bio-environmental and cryo-electron microscopy research team to improve the resolution of the target protein structure. Besides, the use of gold nanoparticle-labeling methods and microfluidics chambers to track intracellular protein interactions will be helpful to understand the relationship between protein pathways and neuronal degeneration process. The understanding of the molecular mechanism will be assisted to the treatment of human diseases and drug design and development. We hope that this will be the milestone of the pharmaceutical industry and will benefit the well-being of all mankind.冷凍電鏡生物環境電鏡神經退化性疾病結構生物學Cryo-EMBio-EMNeurodegenerative DiseaseStructural Biology