Hsu, Chia-JuiChia-JuiHsuLEE-CHIN WONGWang, Hsin-PeiHsin-PeiWangChung, Yi-ChunYi-ChunChungKao, Te-WeiTe-WeiKaoWeng, Chen-HsiangChen-HsiangWengWEN-CHAU WUSTEVEN SHINN-FORNG PENGWEN-YIH TSENGWANG-TSO LEE2023-11-092023-11-092023-10-2518661947https://scholars.lib.ntu.edu.tw/handle/123456789/637033Gilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the cortico-striato-thalamocortical (CSTC) circuits. Neuroimaging studies have shown GTS's extensive impact on the entire brain. However, due to participant variability and potential drug and comorbidity impact, the results are inconsistent. To mitigate the potential impact of participant heterogeneity, we excluded individuals with comorbidities or those currently undergoing medication treatments. Based on the hypothesis of abnormality within the CSTC circuit, we investigated microstructural changes in white matter using diffusion spectrum imaging (DSI). This study offers the first examination of microstructural changes in treatment-naïve pediatric patients with pure GTS using diffusion spectrum imaging.enDiffusion spectrum imaging; False discovery rate; Frontostriatal; Gilles de la Tourette syndrome; Pediatric neurologyjournal article10.1186/s11689-023-09501-0378806312-s2.0-85174976060https://api.elsevier.com/content/abstract/scopus_id/85174976060