KUO-HSING CHENYU-YUN SHAOZHONG-ZHE LINYeh Y.-C.Wen-Yi S.Kuo R.N.Chen H.-M.Lai C.-L.KUN-HUEI YEHANN-LII CHENGLai M.-S.2022-06-102022-06-1020141083-7159https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906976720&doi=10.1634%2ftheoncologist.2013-0423&partnerID=40&md5=dba0156cd16e51069e2fea0e12e9606ehttps://scholars.lib.ntu.edu.tw/handle/123456789/612571BACKGROUND: We investigated the association between diabetes mellitus (DM) and the prognosis of patients with early colon cancer who had undergone curative surgery. METHODS: From three national databases of patients in Taiwan, we selected a cohort of colon cancer patients who had been newly diagnosed with stage I or stage II colon cancer between January 1, 2004 and December 31, 2008 and had undergone curative surgery. We collected information regarding DM (type 2 DM only), the use of antidiabetic medications, other comorbidities, and survival outcomes. The colon cancer-specific survival (CSS) and the overall survival (OS) were compared between patients with and without DM. RESULTS: We selected 6,937 colon cancer patients, among whom 1,371 (19.8%) had DM. The colon cancer patients with DM were older and less likely to receive adjuvant chemotherapy but had a similar tumor stage and grade, compared with colon cancer patients without DM. Compared with colon cancer patients without DM, patients with DM had significantly shorter OS (5-year OS: 71.0% vs. 81.7%) and CSS (5-year CSS: 86.7% vs. 89.2%). After adjusting for age, sex, stage, adjuvant chemotherapy, and comorbidities in our multivariate analysis, DM remained an independent prognostic factor for overall mortality (adjusted hazards ratio: 1.32, 95% confidence interval: 1.18-1.49), but not for cancer-specific mortality. Among the colon cancer patients who had received antidiabetic drug therapy, patients who had used insulin had significantly shorter CSS and OS than patients who had not. CONCLUSION: Among patients who receive curative surgery for early colon cancer, DM is a predictor of increased overall mortality.[SDGs]SDG3journal article10.1634/theoncologist.2013-0423250610902-s2.0-84906976720