2023-01-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/703713模擬分析角膜的透明結構以增進可見光穿透隨機介質的可行性 生醫光學技術的應用範圍大致取決於光穿透生物組織的深度。利用PSTD演算法來計算馬克士威方程式的數值解，以模擬光在巨觀隨機介質中的傳播。我們的研究目標是探究促成穿透度的關鍵幾何結構因子，分析模擬光波入射類似角膜結構的長圓柱體群，計算光場的相位與強度的分佈，來探討透明度與膠原纖維（collagen fibrils）幾何結構的關係。模擬光的散射分佈，來分析透明度與隨機介質之幾何因子的關聯性。前導研究的模擬結果支持我們的研究假設；本計畫的研究方法確能幫助了解提升光入射生物組織結構的穿透性。從更廣的層面來看，本計劃的研究成果能提升光穿透不規則隨機介質的穿透，進而擴展各個領域光學技術的應用深度。 Simulation analysis to enhance light transmission through cornea via phase interference Biomedical optics involve propagation of light through biological scattering media; thus, its applicability depends on the effectiveness of light transmission through biological tissue. By means of numerical solutions of Maxwell’s equations using the pseudospectral time-domain (PSTD) algorithm, we investigate light propagation through scattering media of macroscopic dimensions. Our research objective is to decipher geometrical factors that contribute to transparency. Specifically, we model wave propagation through a cornea-like aggregation of fibril cluster consisting long, dielectric cylinders; by comparing the transmitted light profile, we analyze the relationship of transparency and opacity to the different fibril structures. Preliminary simulations showed results supporting our hypothesis; the proposed research may provide critical information to increase the penetration depth of light propagation through biological tissues; furthermore, it may enhance light propagation through scattering medium and is applicable to optics techniques in general.PSTD 模擬;散射;透明;角膜;同向性;干涉;馬克士威方程式。;PSTD simulation; scattering; transparency; cornea; coherence; interference; Maxwell’s equations.