Yang Y.-F.Chen C.-Y.Lu T.-H.CHUNG-MIN LIAOYI-FAN YANG2020-01-142020-01-1420190304-3894https://scholars.lib.ntu.edu.tw/handle/123456789/448895While a large body of literature has shown that microplastics (MPs) are highly likely to be accumulated in marine organisms and terrestrial animals, information about toxicity of MPs in mammal from a mechanistic point of view is more limited. Our paper fills this knowledge gap by assessing polystyrene (PS)-MPs-mice system based on toxicity-based toxicokinetic/toxicodynamic (TBTK/TD) modeling to quantify organ-bioaccumulation and biomarker responses appraised with published dataset. The key TBTK-parameters for mice liver, kidney, and gut posed by 5 or 20 μm PS-MPs could be obtained. We found that gut had the highest bioaccumulation factor (BCF) of ∼8 exposed to 5 μm PS-MPs with a mean residence time of ∼17 days. We showed that threshold concentrations of 5 and 20 μm PS-MPs among the most sensitive biomarkers were 8 ± 5 (mean ± SE) and 0.71 ± 0.14 μg g−1 bw, respectively, implicating that particle size was likely to affect TK/TD behavior in mice. The mice-based TK parameters and threshold criteria greatly assist in designing robust researches to evaluate MP consumption by humans. We establish a TBTK/TD framework for mechanistically assessing potential from mice size-specific MPs exposure that would offer a tool-kit for extrapolating to humans from health risk assessment perspective. © 2018 Elsevier B.V.[SDGs]SDG3[SDGs]SDG14Bioaccumulation; Biomarkers; Health risks; Marine biology; Microplastic; Particle size; Polystyrenes; Risk assessment; Toxicity; Bioaccumulation factor; Biomarker response; Mean residence time; Mice; Microplastics; Terrestrial animals; Threshold concentrations; Toxicokinetics; Mammals; adenosine triphosphate; catalase; plastic; polystyrene derivative; superoxide dismutase; triacylglycerol; polystyrene derivative; assessment method; bioaccumulation; biomarker; concentration (composition); marine environment; parameter estimation; plastic waste; pollution exposure; polymer; risk assessment; rodent; toxicity; animal experiment; Article; bioaccumulation; controlled study; health hazard; intestine; kidney; lipid metabolism; liver; male; mean residence time; mouse; no-observed-adverse-effect level; nonhuman; oxidative stress; risk assessment; steady state; toxicokinetics; animal; metabolism; Animalia; Mammalia; Mus; Animals; Mice; Microplastics; Polystyrenes; Risk Assessment; Toxicokineticsjournal article10.1016/j.jhazmat.2018.12.0482-s2.0-85058801513https://www2.scopus.com/inward/record.uri?eid=2-s2.0-85058801513&doi=10.1016%2fj.jhazmat.2018.12.048&partnerID=40&md5=9d85da6a5904274cc86054630770dea9