流行病學研究所;Graduate Institute of EpidemiologyHUNG, CHIN-CHUANCHIN-CHUANHUNGTAI, JOHN, JENJOHN, JENTAILIN, CHUN-JUNGCHUN-JUNGLIN2008-09-302018-06-292008-09-302018-06-292005http://ntur.lib.ntu.edu.tw//handle/246246/82026Objectives The aim of this study was to investigate the association of the complex haplotype system of ABCB1 gene with the epilepsy treatment response. Methods and results Ten polymorphisms were genotyped in 108 drug-resistant epileptic patients, 223 seizure-free patients and 287 normal controls. Highly significant linkage disequilibrium was shown among exon 12 C1236T, exon 21 G2677 T and exon 26 C 3435T. Haplotypic analysis demonstrated that patients with the C-G-C, T-G-C, and T-T-T haplotypes were more likely to be drug-resistant. Further analysis of haplotype combinations demonstrated that drug-resistant patients tended to have the CGC/CGC, CGC/TGC, CGC/TTT and TGC/TTT haplotype combinations over the seizure-free patients and controls (all p-values<0.0001). In contrast, patients with the TTC/TTC, TTC/CGT, TTC/TGT, CGT/CGT and TGT/CGT haplotype combinations were more likely to be seizure- free (all p- values<0.0001 except CGT/CGT (p=0.0063))./CGT haplotype combinations were more likely to be seizure- free (all p- values<0.0001 except CGT/CGT (p=0.0063)).en-USMDR1polymorphismsepilepsylinkage disequilibriumjournal article