2013-10-092024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/678327摘要：多孔性無機材料(Porous inorganic materials)是指具有孔徑之無機材料，這類型的材料擁有大的比表面積(Surface area)可進行吸附並提供較多催化反應所需的反應位置（Reaction site），因此在生質能源轉化以及藥物傳遞有極大的應用潛力。本研究將使用常見的氧化物材料如二氧化矽(Silica, SiO2)、二氧化鈦(Titania, TiO2)、氧化鋅(Zinc oxide, ZnO)及二氧化錫(Tin Oxide, SnO2)等作為擔體，先藉由調整材料尺寸、孔徑大小以及表面形貌等方式進行研究；接著依照催化及藥物傳遞應用之需求分別進行表面修飾：在生質能源轉化方面，本研究將固定酵素(Enzyme)或是奈米金屬粒子(metal nanoparticles)於多孔性無機材料上，將纖維素(Cellulose)直接轉換成葡萄糖(Glucose)、果糖(Fructose)或是5-羥甲基糠醛(5-hydroxymethylfurfural, HMF)；在藥物載體的部分，本研究將利用多孔性無機材料擁有大表面積可吸附較多特定藥物並利用適當的適體(aptamer)修飾氧化物材料使其可具有生物辨識的能力，進行特定區域標靶治療。<br> Abstract: Porous inorganic materials are consisting of inorganic elements and containing pores with pore size from about 3 A to over 500 A. Porous materials provide many adsorption and reaction sites owing to large surface area, which might promise potential application in biomass conversion and drug delivery. Herein, oxides, such as silica (SiO2), titania (TiO2), zinc oxide (ZnO), and tin oxide (SnO2), are used as supporting materials. To achieve the goal of each application, the synthetic strategy will be applied to tune particle size, pore diameter, and surface morphology. In addition, suitable surface modification methodology will be implemented. In biomass conversion, enzymes and metal nanoparticles are expected to be immobilized on the supporting materials to converse cellulose to glucose, fructose, or 5-hydroxymethylfurfural. In drug delivery, the larger drug adsorption is expected because of large surface area of porous materials and then aptamer will bind to the porous materials surface to enhance biometric identification and be propitious to targeted therapy of specific region.多孔性無機材料生質能源藥物傳遞氧化物表面修飾porous inorganic materialsbiomassdrug deliveryoxidessurface modification