MiR-503 pleiotropically regulates epithelial-mesenchymal transition and targets PTK7 to control lung cancer metastasis

TZU-HSIU TSAIGow, Chien-HungChien-HungGowLiu, Yi-NanYi-NanLiuTsai, Meng-FengMeng-FengTsaiChang, Tzu-HuaTzu-HuaChangSHANG-GIN WUMIN-SHU HSIEHKANG-YI SUJIN-YUAN SHIH2023-07-032023-07-032023-05-222045-7634https://scholars.lib.ntu.edu.tw/handle/123456789/633288In lung cancer patients, most deaths are caused by the distant dissemination of cancer cells. Epithelial-mesenchymal transition (EMT) and collective cell migration are distinct and important mechanisms involved in cancer invasion and metastasis. Additionally, microRNA dysregulation contributes significantly to cancer progression. In this study, we aimed to explore the function of miR-503 in cancer metastasis.enactin cytoskeleton; epithelial-mesenchymal transition; focal adhesion kinase; miR-503; protein tyrosine kinase 7[SDGs]SDG3MiR-503 pleiotropically regulates epithelial-mesenchymal transition and targets PTK7 to control lung cancer metastasisjournal article10.1002/cam4.6116372124852-s2.0-85159815858https://api.elsevier.com/content/abstract/scopus_id/85159815858