Xu, J.J.XuLiu, Y.Y.LiuHsu, S.-H.S.-H.HsuSHAN-HUI HSU2020-03-022020-03-02201914203049https://scholars.lib.ntu.edu.tw/handle/123456789/467538Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and functions after damages. Moreover, pH-sensitivity of the Schiff base offers the hydrogels response to biologically relevant stimuli. Different types of Schiff base can provide the hydrogels with tunable mechanical properties and chemical stabilities. In this review, we summarized the design and preparation of hydrogels based on various types of Schiff base linkages, as well as the biomedical applications of hydrogels in drug delivery, tissue regeneration, wound healing, tissue adhesives, bioprinting, and biosensors. © 2019 by the authors.Click chemistry; Dynamic covalent bond; Hydrogel; Schiff base; Self-healing; Tissue engineeringSchiff base; tissue adhesive; animal; chemistry; click chemistry; drug delivery system; drug effect; human; hydrogel; procedures; wound healing; Animals; Click Chemistry; Drug Delivery Systems; Humans; Hydrogels; Schiff Bases; Tissue Adhesives; Wound Healingreview10.3390/molecules24163005314309542-s2.0-85070751386https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070751386&doi=10.3390%2fmolecules24163005&partnerID=40&md5=e818690829cbefcf1ab59f17463e2c38