外科YANG, CHANG-HSUEHCHANG-HSUEHYANGLEE, WEI-JEIWEI-JEILEEWANG, HSIH-HSIHSIH-HSIWANGHUANG, SHIH-PEISHIH-PEIHUANGLIN, JAW-TOWNJAW-TOWNLINWU, MING-SHIANGMING-SHIANGWU2009-09-282018-07-112009-09-282018-07-112006http://ntur.lib.ntu.edu.tw//handle/246246/92902Background: There are few data relating to the role of H. pylori infection and surgical procedures on the occurrence of gastric ulcer following bariatric surgery. Methods: Subjects with upper gastrointestinal symptoms after bariatric surgery and receiving gastroscopic examinations were prospectively enrolled. All clinical data including age , sex, BMI before surgery, and surgical method were recorded . IgG antibodies against H. pylori were measured in preoperative serum by enzyme-linked immunosorbent assay ( ELISA). Results: A cohort of 636 patients undergoing laparoscopic vertical banded gastroplasty (LVBG) or Roux-en- Y gastric bypass (LRYGBP) was recruited. The seropositivity of H. pylori in symptomatic and asymptomatic patients after surgery was 39%.(32/82) and 39 .7% (220/554) respectively. Endoscopic examinations revealed that 22 (26.8 %) of 82 symptomatic patients had a gastric ulcer. Comparison of demographic characteristics between patients with ulcer (n = 22) and patients without ulcer (n = 60) showed no difference in distribution of gender, age, BMI, and seroprevalence of H. pylori (27.3%, 6/22 vs 43.3%, 26/60, P= 0.212). Patients undergoing LRYGBP showed a higher rate of gastric ulcer (45.5%, 10/22) when compared to patients undergoing LVBG (20 %, 12/60; P = 0.027). Conclusion: Gastric ulcers in symptomatic patients following laparoscopic bariatric surgery are related to surgical procedures rather than exposure to A pylori infection.en-USgastric ulcerbariatric surgerymorbid obesityHelicobacter pylorigastroplastygastric bypass[SDGs]SDG3journal article