ANDY SUNJEAN-SAN CHIAWON-BO WANGCHUN-PIN CHIANG2019-09-022019-09-0220040192-415Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-3543019185&doi=10.1142%2fS0192415X04001886&partnerID=40&md5=7a7c21eb219af721fb8599f02e86da1dhttps://scholars.lib.ntu.edu.tw/handle/123456789/417102Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. In our institution, an immunomodulating agent, levamisole, is used to treat RAU with satisfactory therapeutic effect. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. To test whether THL has immunomodulating effects on antigen-stimulated proliferation response (PR) of peripheral blood mononuclear cells (PBMC) and T-cells isolated from RAU patients and to test whether THL is a potential drug for treating RAU, PBMC or T-cells isolated from RAU patients were incubated with lipopolysaccharides (LPS) from Escherica coli, phytohemagglutinin (PHA), staphylococcal enterotoxin B (SEB), glutaraldehyde-inactivated tetanus toxoid (TT), glucosyltransferase D (GtfD), or antigens of Streptococcus mutans in the presence or absence of THL. We found that THL significantly increased the LPS-stimulated PR of PBMC from active RAU patients, the GtfD-stimulated PR of PBMC and of T-cells from inactive RAU patients, and the S. mutans-stimulated PR of PBMC from inactive RAU patients. However, THL could also significantly reduce the SEB-stimulated PR of PBMC and of T-cells from active RAU patients and S. mutans-stimulated PR of T-cells from active RAU patients. These results suggest that THL can modulate the antigen-stimulated PR of PBMC and T-cells from RAU patients. Therefore, it may be a potential immunoceutical agent for treatment of RAU. ? 2004 World Scientific Publishing Company.en-US[SDGs]SDG3astragalus extract; Atractylodes extract; bacterium lipopolysaccharide; Chinese drug; Clematidis extract; Cordyceps sinensis extract; ginseng extract; glucosyltransferase; glutaraldehyde; Glycyrrhiza extract; herbaceous agent; immunomodulating agent; Indigo extract; Ligustrum lucidum extract; Margarita extract; Oldenlandia diffusa extract; phytohemagglutinin; plant extract; Pogostemon cablin extract; Polyporus umbellatus extract; solanum nigrum extract; Staphylococcus enterotoxin B; Streptococcus antigen; tetanus toxoid; Trichosanthis extract; unclassified drug; adolescent; adult; aged; article; Astragalus plant; Atractylodes; cell isolation; cell proliferation; cell stimulation; Clematidis; clinical article; controlled study; Cordyceps; Escherichia coli; female; ginseng; Glycyrrhiza; human; immunomodulation; immunostimulation; incubation time; indigo; Ligustrum; liquid; male; Margarita; medicinal plant; mouth ulcer; Oldenlandia; peripheral blood mononuclear cell; pogostemon cablin; Polyporus; recurrent disease; Solanum nigrum; Staphylococcus; Streptococcus mutans; T lymphocyte; treatment planning; Trichosanthis; Cell Culture Techniques; Cell Division; Drugs, Chinese Herbal; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Stomatitis, Aphthous; T-Lymphocytesjournal article10.1142/S0192415X04001886153152602-s2.0-3543019185